RA position

Research Associate : Mathematical modelling of the infection dynamics of human and animal African trypanosomiasis

Application deadline 1st April 2019.


We are currently recruiting for a Research Associate at the University of Glasgow, to join an innovative project funded by the Wellcome Trust, investigating trypanosome antigenic variation paradigms using natural systems. This is an interdisciplinary collaboration between Universities of Glasgow, Edinburgh and Liverpool. The position is for 2.5 years (there may be the possibility of extending). The post-holder will be supervised by Dr Christina Cobbold within the School of Mathematics and Statistics, collaborating closely with experimentalists to develop novel mathematical models of antigenic variation.

Ideally we will be looking for someone PhD qualified, or working towards their PhD, in Mathematical Biology or other relevant quantitative subject such as statistics, physics or infectious disease epidemiology with a strong quantitative component. Candidates should be skilled in one or more common programming languages such as Matlab, R, Python, Fortran, C++ or similar. Experience of Bayesian inference, infectious disease modelling, epidemiology and interaction with biologists would be beneficial, but not necessary.

About the project

Trypanosomes are parasites that cause African sleeping sickness, and are masters of disguise. They can hide from our immune system by replacing the proteins on their surface, constantly changing to avoid being recognised and destroyed. This process (a phenomenon known as antigenic variation or AV) has been studied by scientists for over forty years and its molecular details are well known, at least for one species of the parasite, Trypanosoma brucei. However, this is not the most important trypanosome species in sub Saharan Africa, and most of our knowledge is based on laboratory studies that may not well represent how the parasite operates in the real-world.

The aim of this project is to develop models and tools to uncover how the most prevalent trypanosomes, Trypanosoma congolense and Trypanosoma vivax, establish infections and survive in animals, where they cause enormous economic hardship through a livestock disease in Africa called 'nagana'. This name is derived from the Zulu word for 'useless', highlighting the devastating impact the parasite has on afflicted cattle. We think these important livestock trypanosomes are doing things very differently. Our project has the possibility to identify vulnerable points in the parasite's defences that could be targeted using drug therapy or even vaccines - something previously considered impossible.

The research project will systematically compare antigenic variation in different trypanosome species and hosts, and analyse the effects of key molecular regulators of the infection dynamic, information that we anticipate could be exploited to help combat the parasite and may be relevant for other pathogens that use antigenic variation for survival. A core goal of the project is to link cutting-edge quantitative and modelling techniques with the unique genome-wide genetic and cell culture data sets being produced by the Wellcome Trust project team that the post-holder will be part of.

Our research team and research environment

This project involves interdisciplinary collaborations with international colleagues in Edinburgh (Professor Keith Matthews, Dr Liam Morrison, Achim Schnaufer), Glasgow (Dr Richard McCulloch), Liverpool (Dr Andrew Jackson), Lisbon (Dr Luisa Figueiredo), Heidelberg ( Prof Nina Papavasiliou) and Baltimore(Dr Monica Mugnier).

The post-holder will be based in the School of Mathematics and Statistics and will also be embedded in an award-winning research environment by joining the Boyd Orr Centre for Population and Ecosystem Health which synthesises clinical and ecological expertise, with a particular focus on integrating mathematical modelling with empirical data. The Centre holds regular working groups and seminars and is a vibrant environment for discussions and exchanging research ideas.

Some relevant publications

  • E. Gjini, D.T. Haydon, J.D. Barry, C.A. Cobbold: Critical interplay between parasite differentiation, host immunity and antigenic variation in trypanosome infections. Am. Nat.176(4): 424-439 (2010). Full paper (PDF)
  • E. Gjini, D. T. Haydon, J.D.Barry and C. A. Cobbold Linking the antigen archive structure to pathogen fitness in African trypanosome Proceedings of the Royal Society London Series B 280(1753): 20122129 (2013) Full paper (PDF)
  • R McCulloch, CA Cobbold, L Figueiredo, A Jackson, LJ Morrison, and others: Emerging challenges in understanding trypanosome antigenic variation . Emerging topics in life sciences 1 (6), 585-592 (2017) Full paper (PDF)
  • E. Gjini, D. T. Haydon, J.D.Barry, & C. A. Cobbold The impact of mutation and gene conversion on the local diversification of antigen genes in African trypanosomes. Molecular Biology and Evolution 29(11): 3321-3331 (2012) Full paper (PDF)

    Working at the University of Glasgow

    Founded in 1451, the University of Glasgow is the fourth-oldest university in the English-speaking world and one of Scotland's four ancient universities. The university is home to a vibrant and diverse community of students, researchers, and visiting scholars from around the world, with numerous seminars, working groups and social events.

    Glasgow is a cultural city with a large selection of museums, theatres, live music venues and it's the home of the Scottish Opera, the Scottish Ballet, the Royal Scottish National Orchestra and other arts organisations. The city is surrounded by beautiful countryside including the stunning Loch Lomond and the Trossachs National Park (www.lochlomond-trossachs.org).

    How do I apply?

    To apply please complete the online application form by following the link and searching for vacancy reference 023261. Full details of the job description and salary can be found on this page. Informal enquiries can be also be made to Christina Cobbold